The cinematic classic Teen Wolf fits that description.
Here’s the clif notes version for those that have not watched the movie (shame on you btw).
High school athlete turns into a werewolf when “excited”, as opposed to normal stress responses, and rather than face almost assured shaming and humiliation, he uses this affliction to become the most popular kid in school and to do impossible dunks.
Simple premise: Werewolf movie.
Interesting twist: He is actually popular instead of being called the “hairy kid.”
It’s weird how things like that happen. All logic would indicate that this movie has too simple a premise and be a waste of time. As anyone that has ever watched Teen Wolf knows. This movie rocks..
Sometimes the most complex problems like movie scripts, require the simplest solutions.